All specialtiesCritical Care
Critical Care Evidence Evolution
5 evidence evolution narratives tracing how landmark trials and guideline updates reshaped critical care practice.
4.12001-2023
Sepsis Fluid Resuscitation
From protocolized bundles to balanced restraint
Rivers EGDT (2001) → ProCESS/ARISE/ProMISe → balanced vs saline (SMART) → restrictive
Rivers EGDTProCESSARISEProMISeSMARTCLOVERS
Read evolution
4.22000-2023
Lung-Protective Ventilation in ARDS
The tidal volume revolution
High TV norm → ARDSNet ARMA (2000) → driving pressure → PEEP → prone (PROSEVA)
ARMAALVEOLIPROSEVAART
Read evolution
4.32008-2023
Vasopressor Selection in Septic Shock
Beyond the dopamine era
Dopamine default → norepinephrine-first → vasopressin adjunct → angiotensin II
SOAP IIVASSTVANISHATHOS-3
Read evolution
4.42001-2023
Prone Positioning in ARDS
From unproven maneuver to standard of care
Unproven → negative trials → PROSEVA breakthrough (2013) → awake proning
Gattinoni 2001PROSEVACOVID awake prone
Read evolution
4.52001-2023
ICU Glucose Control
The pendulum swings
Leuven tight control → NICE-SUGAR harm (2009) → moderate targets → CGM pilots
LeuvenNICE-SUGARTGC-Fast
Read evolution