Dermatology Evidence Evolution

5 evidence evolution narratives tracing how landmark trials and guideline updates reshaped dermatology practice.

Psoriasis Biologics

A revolution in skin clearance

MTX/cyclosporine → anti-TNF (REVEAL/PHOENIX) → IL-17 (ERASURE/FIXTURE) → IL-23 (VOYAGE/ULTIMMA)

From topical steroids to targeted biologics

Topical only → cyclosporine → dupilumab (SOLO/CAFE) → JAK inhibitors

From decades of futility to durable responses

Dacarbazine → ipilimumab (2011) → nivolumab/pembrolizumab → combination → adjuvant

From dermoscopy to AI-powered screening

Clinical exam → dermoscopy → teledermatology → AI (Esteva 2017) → FDA clearances

Rethinking the gold standard for acne

High-dose → iPLEDGE → low-dose/intermittent → depression link debates