Obstetrics & Gynecology Evidence Evolution

5 evidence evolution narratives tracing how landmark trials and guideline updates reshaped obstetrics & gynecology practice.

Preeclampsia Aspirin Prevention

Screen and prevent in the first trimester

No prevention → aspirin trials → ASPRE (2017) → first-trimester screening + aspirin → timing

One step or two?

No standard → O'Sullivan (1964) → HAPO (2008) → IADPSG → one-step vs two-step debate

From Pap smear to HPV primary

Pap alone → liquid-based → HPV co-testing → HPV primary → extended intervals → vaccine impact

Challenging the wait

Await spontaneous → ARRIVE (2018) → lower cesarean with induction → practice change

Rise and fall of 17-OHPC

No prevention → 17-OHPC (Meis 2003) → widespread → PROLONG (2019) negative → FDA withdrawal → vaginal persists