Ophthalmology Evidence Evolution

5 evidence evolution narratives tracing how landmark trials and guideline updates reshaped ophthalmology practice.

Anti-VEGF Therapy for Wet AMD

Saving sight with injections

Laser → PDT → ranibizumab (MARINA/ANCHOR 2006) → bevacizumab (CATT) → aflibercept → treat-and-extend → biosimilars

Laser before drops

Drops first → LiGHT (2019) SLT first → cost-effective → drop-free initial management

Autonomous diagnosis

Ophthalmologist-only → teleretinal → IDx-DR first FDA AI (2018) → autonomous screening → integration

Tailoring the artificial lens

Monofocal → multifocal → EDOF → toric → LAL → femtosecond → patient selection

Imaging the invisible

Clinical exam + FA → time-domain OCT → SD-OCT → swept-source → OCTA → AI interpretation