Landmark TrialRCTRandomized Controlled Trial
Immunosuppressive therapy in lupus nephritis: The Euro‐Lupus Nephritis Trial, a randomized trial of low‐dose versus high‐dose intravenous cyclophosphamide
Arthritis & Rheumatism2002
Frédéric Houssiau Carlos Vasconcelos David D’Cruz Gian Domenico Sebastiani Enrique de Ramón Garrido Maria Giovanna Danieli Daniel Abramovicz Daniël Blockmans Alessandro Mathieu Haner Di̇reskeneli̇ Mauro Galeazzi Ahmet Gül Yair Levy P Petera Rajko Popović Radmila Petrović Renato Alberto Sinico Roberto Cattaneo Josep Font Geneviève Depresseux Jean‐Pierre Cosyns Ricard Cervera
Abstract
The data from the ELNT indicate that in European SLE patients with proliferative lupus nephritis, a remission-inducing regimen of low-dose IV CYC (cumulative dose 3 gm) followed by AZA achieves clinical results comparable to those obtained with a high-dose regimen.