Landmark TrialRCTRandomized Controlled Trial
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
Arthritis & Rheumatism2005
Y P M Goekoop-Ruiterman Jeska K de Vries‐Bouwstra Cornelia F Allaart D. van Zeben P. J. S. M. Kerstens Johanna M W Hazes A. H. Zwinderman H. K. Ronday K. H. Han M L Westedt A. Gerards J.H.L.M. van Groenendael Willem F. Lems M V van Krugten F. C. Breedveld Ben A. C. Dijkmans
Abstract
In patients with early RA, initial combination therapy including either prednisone or infliximab resulted in earlier functional improvement and less radiographic damage after 1 year than did sequential monotherapy or step-up combination therapy.