RCTRandomized Controlled Trial
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
The Lancet. Oncology2006
Walter Stummer Uwe Pichlmeier Thomas Meinel Otmar Dieter Wiestler Friedhelm Zanella Hans-Jürgen Reulen
PMID: 16648043View on PubMed
Abstract
5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. We aimed to assess the effect of fluorescence-guided resection with 5-aminolevulinic acid on surgical radicality, progression-free survival, overall survival, and morbidity.