Landmark TrialRCTRandomized Controlled Trial
Surgical versus Nonsurgical Treatment for Lumbar Degenerative Spondylolisthesis
New England Journal of Medicine2007IF: 25.4
James N. Weinstein, Jon D. Lurie, Tor D. Tosteson, Brett Hanscom, Anna N.A. Tosteson, Emily Blood, Nancy J. O. Birkmeyer, Alan S. Hilibrand, Harry N. Herkowitz, Frank P. Cammisa, Todd J. Albert, Sanford E. Emery, Lawrence G. Lenke, William A. Abdu, Michael Longley, Thomas J. Errico, Serena S. Hu
Abstract
In nonrandomized as-treated comparisons with careful control for potentially confounding baseline factors, patients with degenerative spondylolisthesis and spinal stenosis treated surgically showed substantially greater improvement in pain and function during a period of 2 years than patients treated nonsurgically. (ClinicalTrials.gov number, NCT00000409 [ClinicalTrials.gov].).