Landmark TrialRCTRandomized Controlled Trial
A Multicenter, Randomized, Controlled Trial of Dexamethasone for Bronchiolitis
New England Journal of Medicine2007IF: 25.4
Howard M. Corneli, Joseph J. Zorc, Prashant Mahajan, Kathy N. Shaw, Richard Holubkov, Scott D. Reeves, Richard M. Ruddy, Baqir Malik, Kyle A. Nelson, Joan Bregstein, Kathleen Brown, Matthew N. Denenberg, Lois K. Lee, Lynn Babcock Cimpello, James W. Tsung, Dominic Borgialli, Marc N. Baskin, Getachew Teshome, Mitchell Goldstein, David Monroe, Jay B. Dean, Nathan Kuppermann
Abstract
In infants with acute moderate-to-severe bronchiolitis who were treated in the emergency department, a single dose of 1 mg of oral dexamethasone per kilogram did not significantly alter the rate of hospital admission, the respiratory status after 4 hours of observation, or later outcomes. (ClinicalTrials.gov number, NCT00119002 [ClinicalTrials.gov].).