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The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital
The Journal of Trauma: Injury, Infection, and Critical Care2007
Matthew A. Borgman, Philip C. Spinella, Jeremy G. Perkins, Kurt W. Grathwohl, Thomas B. Repine, Alec C. Beekley, James Sebesta, Donald H. Jenkins, Charles E. Wade, John B. Holcomb
Abstract
In patients with combat-related trauma requiring massive transfusion, a high 1:1.4 plasma to RBC ratio is independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage. For practical purposes, massive transfusion protocols should utilize a 1:1 ratio of plasma to RBCs for all patients who are hypocoagulable with traumatic injuries.