Landmark TrialRCTRandomized Controlled Trial
Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
New England Journal of Medicine2009IF: 25.4
Jonathan C. Craig, Judy M. Simpson, Gabrielle Williams, A. Lowe, Graham Reynolds, Steven McTaggart, Elisabeth M Hodson, Jonathan R. Carapetis, Noel Cranswick, Grahame Smith, Les Irwig, Patrina Caldwell, Sana Hamilton, Leslie P. Roy
Abstract
Long-term, low-dose trimethoprim-sulfamethoxazole was associated with a decreased number of urinary tract infections in predisposed children. The treatment effect appeared to be consistent but modest across subgroups. (Australian New Zealand Clinical Trials Registry number, ACTRN12608000470392.)