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Post-MI Secondary Prevention (ESC 2023)

Post-MI Secondary Prevention (ESC 2023): Post-MI Patient → Antithrombotic Therapy → Beta-Blocker → SGLT2 Inhibitor → ICD Evaluation.

Pathway Overview

10 steps

Algorithm Steps

10 total

  1. 01Start

    Post-MI Patient

    After STEMI or NSTEMI

  2. 02Action

    Antithrombotic Therapy

    DAPT then maintenance

    • DAPT x 12 months
    • Aspirin + Ticagrelor/Prasugrel
    • Then aspirin indefinitely
  3. 03Action

    Beta-Blocker

    ≥1 year, indefinite if HF

    • Carvedilol, bisoprolol, metoprolol
    • Indefinite if LVEF ≤40%
    • Indefinite if arrhythmia/HF
  4. 04Action

    SGLT2 Inhibitor

    If HFrEF/HFmrEF/DM/CKD

    • Dapagliflozin or empagliflozin
    • Growing evidence post-MI
  5. 05Warning

    ICD Evaluation

    At ≥40 days post-MI

    • If LVEF ≤35% despite OMT x 3mo
    • Primary prevention SCD
  6. 06Outcome

    Lifelong Secondary Prevention

    Regular follow-up, optimize GDMT

  7. 07Action

    Cardiac Rehabilitation

    Class I recommendation

    • Exercise training
    • Risk factor education
    • Psychosocial support
  8. Path rejoins step 06Shared downstream outcome
  9. 08Action

    Lipid Therapy

    Aggressive LDL lowering

    • Target: LDL <55 mg/dL + ≥50% reduction
    • Recurrent event: <40 mg/dL
    • Step 1: High-intensity statin
    • Step 2: + Ezetimibe
    • Step 3: + PCSK9i
  10. 09Action

    ACEi/ARB/ARNI

    All post-STEMI patients

    • Especially if LVEF ≤40%
    • Anterior MI, HTN, DM
    • ARNI if HF develops
  11. Path rejoins step 04Shared downstream outcome
  12. 10Action

    MRA

    If LVEF ≤40% + symptoms/DM

    • Spironolactone or eplerenone
    • Monitor K+ and renal function
  13. Path rejoins step 04Shared downstream outcome

Guideline Source

ESC 2019 Dyslipidemia + ESC 2023 ACS Guidelines

Clinical Safety Information

Clinical Decision Support — Not a Substitute for Clinical Judgment

Individual patient factors may require deviation from these recommendations.

Known Limitations

  • Drug dosing not included
  • Cardiac rehab details simplified
  • Does not address CABG-specific considerations

Contraindicated Populations

pediatric

Applicable Regions

EUUS

EU: ESC targets: LDL <55 mg/dL, <40 if recurrent

US: ACC/AHA similar but LDL targets may differ

Version 1Next review: 2027-01-01

Frequently Asked Questions

What is the Post-MI Secondary Prevention (ESC 2023)?

The Post-MI Secondary Prevention (ESC 2023) is a management clinical algorithm for Cardiology. It provides a structured decision tree to guide clinical decision-making, based on ESC 2019 Dyslipidemia + ESC 2023 ACS Guidelines.

What guideline is the Post-MI Secondary Prevention (ESC 2023) based on?

This algorithm is based on ESC 2019 Dyslipidemia + ESC 2023 ACS Guidelines (DOI: 10.1093/eurheartj/ehz455).

What are the limitations of the Post-MI Secondary Prevention (ESC 2023)?

Known limitations include: Drug dosing not included; Cardiac rehab details simplified; Does not address CABG-specific considerations. Individual patient factors may require deviation from these recommendations.

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